Understanding Type A Insulin Resistance Syndrome
Type A insulin resistance syndrome is a rare disease that causes your body to not process blood sugar well. This happens because insulin can’t be used normally by your body’s cells. The condition also causes other problems, such as skin changes and cysts on the ovaries.
What is insulin resistance?
Insulin is a hormone made by the pancreas. It helps your cells use sugar (glucose) that’s in your bloodstream. Your pancreas makes insulin when your blood sugar level goes up. Insulin resistance is when cells don’t respond to insulin normally. In people with type A insulin resistance syndrome, this can lead to ongoing high blood sugar levels (diabetes).
What causes type A insulin resistance syndrome?
The condition is present at birth. It’s caused by a change (mutation) in one or more genes. This gene change causes cells to not be able to use insulin normally. Experts aren’t sure why the gene changes. You may have a parent with the condition and inherit the gene. Or you may be the only person in your family with the gene change.
Symptoms of type A insulin resistance syndrome
Women often have more symptoms. These can include:
Skin in body folds that turns dark, thicker, and velvety (acanthosis nigricans)
Extra body hair on face, chest, and back
Light and irregular periods, or no periods
Cysts and more scar tissue on the ovaries
Problems with fertility
High levels of the hormone testosterone
Low blood sugar after eating
Men have fewer signs and symptoms. These can include:
Diagnosing type A insulin resistance syndrome
Your healthcare provider will ask about your symptoms and give you a physical exam. You may also have blood tests to check your blood sugar levels.
Treatment for type A insulin resistance syndrome
Researchers are looking for the best ways to treat this condition. Your healthcare provider will talk with you about a treatment plan. You may take a medicine to help lower blood sugar levels, such as metformin. Ask your healthcare provider about clinical trials that you can join.
Living with type A insulin resistance syndrome
You’ll need to keep regular healthcare visits for life to watch your health. The condition can lead to ongoing high blood sugar (diabetes) that requires high doses of insulin to be treated. Over time, high blood sugar can cause diseases of the blood vessels and heart.
When to call your healthcare provider
Call your healthcare provider if you have any of the following: