Medications


Diphenhydramine Topical

What is this medicine?

DIPHENHYDRAMINE (dye fen HYE dra meen) is an antihistamine. It is used on the skin to treat pain and itching from insect bites, sunburns, rashes, and other minor skin conditions.

How should I use this medicine?

This medicine is for external use only. Do not drink or use in the mouth. Follow the directions on the package. Wash your hands before and after use. Apply to the affected area as directed on the package or by your doctor or health care professional. Do not use this medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be used in children as young as 2 years for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • drowsiness or dizziness

  • dry mouth

  • headache

What may interact with this medicine?

Interactions are not expected. Do not use any other skin products on the affected area without asking your doctor or health care professional.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not freeze. Protect from light. Throw away any unused medicine after the expiration date. Some products may contain alcohol or have other flammable components. Do not use while smoking or near heat or flame.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • chicken pox or measles

  • an unusual or allergic reaction to diphenhydramine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better within 7 days or if they get worse. You may have a skin infection or other more serious skin condition.

Do not use this medicine on large areas of the body or with other products that contain diphenhydramine. To do so may increase the risk of side effects.

Do not get this medicine in your eyes. If you do, rinse with plenty of water.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier
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