Medications


Itraconazole capsules and tablets

What is this medicine?

ITRACONAZOLE (i tra KO na zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take after eating a full meal. If you have a condition called achlorhydria, are taking H2-receptor antagonists or other gastric acid suppressors, you should take this medicine with a cola beverage. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • changes in hearing

  • cough up mucus

  • dark urine

  • fast, irregular heartbeat

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • loss of appetite

  • nausea, vomiting

  • pain, tingling, numbness in the hands or feet

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • right upper belly pain

  • sudden weight gain

  • swelling in feet, ankles, or legs

  • unusually weak or tired

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • blurred/double vision

  • diarrhea

  • dizziness

  • headache

  • stomach upset or bloating

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • alfuzosin

  • alprazolam

  • certain medicines for blood pressure like felodipine, nisoldipine

  • certain medicines for cholesterol like cerivastatin, lovastatin, simvastatin, lomitapide

  • certain medicines for the heart like disopyramide, dofetilide, dronedarone, eplerenone, ivabradine, quinidine, ranolazine

  • cisapride

  • colchicine (if you have liver or kidney problems)

  • conivaptan

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • irinotecan

  • lurasidone

  • methadone

  • midazolam

  • nevirapine

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

  • pimozide

  • red yeast rice

  • sirolimus

  • thioridazine

  • triazolam

  • ziprasidone

This medicine may also interact with the following medications:

  • aliskiren

  • amlodipine

  • antacids

  • antiviral medicines for HIV or AIDS

  • aprepitant

  • atorvastatin

  • buprenorphine

  • certain antibiotics like ciprofloxacin, clarithromycin, erythromycin

  • certain medicines for bladder problems like fesoterodine, solifenacin, tolterodine

  • certain medicines for cancer like axitinib, bortezomib, busulfan, dabrafenib, dasatanib, docetaxel, erlotinib, gefitinib, ibrutinib, imatinib, ixabepilone, lapatinib, nilotinib, ponatinib, sunitinib, trabectedin, trimetrexate, vinca alkaloids

  • certain medicines for depression, anxiety, or psychotic disturbances like aripiprazole, buspirone, diazepam, haloperidol, perospirone, quetiapine, risperidone

  • certain medicines for erectile dysfunction like vardenafil, sildenafil, tadalafil

  • certain medicines for pain like alfentanil, fentanyl, oxycodone, sufentanil

  • certain medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole

  • certain medicines that treat or prevent blood clots like warfarin, dabigatran, rivaroxaban

  • certain medicines for seizures like carbamazepine, phenytoin

  • certain medicines for tuberculosis like isoniazid, INH, rifabutin, rifampin, rifapentine

  • cilostazol

  • cinacalcet

  • cyclosporine

  • digoxin

  • eletriptan

  • everolimus

  • halofantrine

  • isradipine

  • meloxicam

  • nadolol

  • nifedipine

  • other medicines for fungal infections

  • praziquantel

  • ramelteon

  • repaglinide

  • salmeterol

  • saxagliptin

  • steroid medicines like budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone

  • tacrolimus

  • tamsulosin

  • tolvaptan

  • verapamil

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease, including angina or heart failure

  • history of irregular heartbeat

  • kidney disease or on dialysis

  • liver disease

  • lung disease

  • an unusual or allergic reaction to itraconazole, or other antifungal medicines, foods, dyes or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for check ups. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Some fungal infections can take many weeks or months of treatment to cure.

Avoid medicines for your stomach like antacids, anticholinergics, and acid blockers for at least 2 hours after taking this medicine.

You may get dizzy or blurred/double vision when taking this medicine. Do not drive, use machinery, or do anything that may be dangerous until you know how the medicine affects you. Do not stand or sit up quickly, especially if you are an older patient.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier
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