Medications


Loperamide; Simethicone oral tablets

What is this medicine?

LOPERAMIDE; SIMETHICONE (loe PER a mide; sye METH i kone) is a combination product used to treat diarrhea and to decrease the discomfort caused by gas.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the label. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years of age for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • bloating

  • signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat palpitations; feeling faint or lightheaded, falls; breathing problems

  • stomach pain

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • dizziness

  • dry mouth

  • nausea, vomiting

  • tiredness

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • alosetron

This medicine may also interact with the following medications:

  • cimetidine

  • clarithromycin

  • erythromycin

  • gemfibrozil

  • itraconazole

  • ketoconazole

  • quinidinequinine

  • ranitidine

  • ritonavir

  • saquinavir

What if I miss a dose?

This does not apply. This medicine is not for regular use. Only take this medicine while you continue to have loose bowel movements. Do not take more medicine than recommended by the packaging label or by your healthcare professional.

Where should I keep my medicine?

Keep out of the reach of children.

Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • blood or mucus in your stools

  • food poisoning

  • currently taking an antibiotic for an infection

  • fever

  • liver disease

  • stomach or intestine problems

  • an unusual or allergic reaction to loperamide, simethicone, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better within two days or if they get worse. Do not use doses higher than those prescribed by your doctor or listed on the label. Check with your doctor or health care professional right away if you develop a fever, severe abdominal pain, swelling or bulging, or if you have have bloody/black diarrhea or stools.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe. Drinking plenty of water can also help prevent dehydration that can occur with diarrhea.

Elderly patients may have a more variable response to the effects of this medicine, and are more susceptible to the effects of dehydration.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier
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