Medications


Alogliptin; Metformin oral tablets

What is this medicine?

ALOGLIPTIN; METFORMIN (al oh GLIP tin; met FOR min) is a combination of 2 medicines used to treat type 2 diabetes. This medicine lowers blood sugar. Treatment is combined with a balanced diet and exercise.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Take this medicine with food. Do not cut this medicine. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • dark urine

  • general ill feeling or flu-like symptoms

  • joint pain

  • light-colored stools

  • loss of appetite

  • muscle pain

  • nausea, vomiting

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • right upper belly pain

  • signs and symptoms of low blood sugar such as feeling anxious, confusion, dizziness, increased hunger, unusually weak or tired, sweating, shakiness, cold, irritable, headache, blurred vision, fast heartbeat, loss of consciousness

  • slow or irregular heartbeat

  • unusual stomach upset or pain

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • headache

  • heartburn

  • metallic taste in the mouth

  • stomach gas, upset

  • stuffy or runny nose

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain contrast medicines given before X-rays, CT scans, MRI, or other procedures

  • dofetilide

  • gatifloxacin

This medicine may also interact with the following medications:

  • acetazolamide

  • alcohol

  • amiloride

  • certain antiviral medicines for HIV infection or hepatitis

  • cimetidine

  • crizotinib

  • digoxin

  • diuretics

  • female hormones, like estrogens or progestins and birth control pills

  • glycopyrrolate

  • isoniazid

  • lamotrigine

  • medicines for blood pressure, heart disease, irregular heart beat

  • memantine

  • methazolamide

  • midodrine

  • morphine

  • nicotinic acid

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • phenytoin

  • procainamide

  • propantheline

  • quinidine

  • quinine

  • ranitidine

  • ranolazine

  • steroid medicines like prednisone or cortisone

  • stimulant medicines for attention disorders, weight loss, or to stay awake

  • thyroid medicines

  • topiramate

  • trimethoprim

  • trospium

  • vancomycin

  • vandetanib

  • zonisamide

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • anemia

  • become easily dehydrated

  • diabetic ketoacidosis

  • heart disease

  • heart failure

  • history of alcohol abuse problem

  • if you often drink alcohol

  • kidney disease

  • liver disease

  • low levels of vitamin B12 in the blood

  • older than 80 years

  • pancreatitis

  • polycystic ovary syndrome

  • previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat

  • serious infection or injury

  • thyroid disease

  • type 1 diabetes

  • undergoing surgery or certain procedures with injectable contrast agents

  • an unusual or allergic reaction to alogliptin, metformin, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.

Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.

Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.

Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.

This medicine may cause ovulation in premenopausal women who do not have regular monthly periods. This may increase your chances of becoming pregnant. You should not take this medicine if you become pregnant or think you may be pregnant. Talk with your doctor or health care professional about your birth control options while taking this medicine. Contact your doctor or health care professional right away if think you are pregnant.

If you are going to need surgery, a MRI, CT scan, or other procedure, tell your doctor that you are taking this medicine. You may need to stop taking this medicine before the procedure.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier
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