Medications


Eluxadoline oral tablets

What is this medicine?

ELUXADOLINE (ee LUX ah dol ine) is an intestinal disorder drug. It is used to treat irritable bowel syndrome with diarrhea.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • constipation

  • right upper belly pain

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizziness

  • nausea, vomiting

  • tiredness

What may interact with this medicine?

This medicine may interact with the following medications:

  • alosetron

  • anticholinergics

  • bupropion

  • certain antibiotics like ciprofloxacin, clarithromycin, rifampin

  • cyclosporine

  • eltrombopag

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • fluconazole

  • gemfibrozil

  • loperamide

  • opiate agonist

  • paroxetine

  • pimozide

  • probenecid

  • quinidine

  • rosuvastatin

  • sirolimus

  • tacrolimus

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • drink more than 3 alcohol-containing drinks per day

  • gallbladder disease

  • have no gallbladder

  • history of constipation

  • history of drug or alcohol abuse problems

  • history of pancreatitis or pancreatic disease

  • liver disease

  • stomach or intestine problems

  • an unusual or allergic reaction to eluxadoline, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

This medicine may cause constipation. If you do not have a bowel movement, call your doctor or healthcare professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier
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