Medications


Perampanel oral suspension

What is this medicine?

PERAMPANEL (per AM pa nel) is used to treat certain types of seizures in patients with epilepsy.

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or dropper to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • anger

  • anxious

  • depressed mood

  • extreme increases in activity and talking

  • hostile or violent behavior

  • irritable

  • suicidal thoughts or other mood changes

  • trouble sleeping

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizziness

  • headache

  • loss of balance or coordination

  • nausea, vomiting

  • stomach pain

  • tiredness

  • weight gain

What may interact with this medicine?

This medicine may interact with the following medications:

  • alcohol

  • antihistamines for allergy, cough and cold

  • certain birth control pills containing levonorgestrel

  • certain medicines for anxiety or sleep

  • certain medicines for depression like amitriptyline, fluoxetine, sertraline

  • certain medicines for fungal infections like ketoconazole

  • certain medicines for seizures like carbamazepine, eslicarbazine, oxcarbazepine, phenobarbital, phenytoin, primidone, topiramate

  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol

  • medicines that relax muscles for surgery

  • narcotic medicines for pain

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • rifampin

  • St. John's wort

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

This medicine may cause accidental overdose and death if it taken by other adults, children, or pets. Mix any unused medicine with a substance like cat litter or coffee grounds. Then throw the medicine away in a sealed container like a sealed bag or a coffee can with a lid. Throw away any unused medicine after 90 days.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F).

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • drug abuse or addiction

  • history of a drug or alcohol abuse problem

  • history of depression or bipolar disorder

  • if you often drink alcohol

  • kidney disease

  • liver disease

  • mental illness

  • suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member

  • an unusual or allergic reaction to perampanel, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.

It is important to take this medicine exactly as directed. When first starting treatment, your dose will need to be adjusted slowly. It may take weeks or months before your dose is stable. You should contact your doctor or healthcare professional if your seizures get worse or if you have any new types of seizures. Do not stop taking this medicine unless instructed by your doctor or healthcare professional. Stopping your medicine suddenly can increase your seizures or their severity.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Some birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier
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