Oritavancin Injection

Brand Name(s): Orbactiv®

WHY is this medicine prescribed?

Oritavancin injection is used to treat skin infections caused by certain types of bacteria. Oritavancin is in a class of medications called lipoglycopeptide antibiotics. It works by killing bacteria.

Antibiotics such as oritavancin will not work for colds, flu, and other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

HOW should this medicine be used?

Oritavancin injection comes as a powder to be mixed with liquid and given through a needle or catheter placed in your vein. It is usually injected slowly over 3 hours as a one-time dose by a doctor or nurse.

You may experience a reaction while you receive a dose of oritavancin. Tell your doctor immediately if you experience any of these symptoms while you receive oritavancin: sudden reddening of the face, neck, upper chest, or other body part; itching; rash; and hives. Your doctor may slow or stop the infusion until your symptoms improve.

You should begin to feel better after receiving treatment with oritavancin injection. If your symptoms do not improve or get worse, call your doctor.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before using oritavancin injection,

  • tell your doctor and pharmacist if you are allergic to oritavancin, dalbavancin (Dalvance), telavancin (Vibativ), vancomycin (Vancocin), any other medications, or any of the ingredients in oritavancin injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are receiving heparin injection. Your doctor will probably stop your heparin for at least 5 days after receiving oritavancin injection.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention warfarin (Coumadin, Jantoven), . Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have any medical conditions.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Oritavancin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • nausea
  • vomiting
  • dizziness
  • headache
  • redness and swelling at the infusion site
  • tachycardia

    Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)
  • swelling of the lips, face, hands, or legs, itching, hives, rash, wheezing
  • signs of new skin infections such as a new painful, red, swollen area on your skin

Oritavancin injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory.

Before having any laboratory test within 5 days of receiving oritavancin, tell your doctor and the laboratory personnel that you have received this medication.

If you still have symptoms of infection after you finishing your treatment with oritavancin injection, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: May 15, 2018.
AHFS® Patient Medication Information™. © Copyright, 2024
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