Omidenepag Isopropyl Ophthalmic

Brand Name(s): Omlonti®

WHY is this medicine prescribed?

Omidenepag isopropyl ophthalmic is used to treat glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision) and ocular hypertension (a condition which causes increased pressure in the eye). Omidenepag isopropyl is in a class of medications called prostaglandin agonists. It lowers pressure in the eye by increasing the flow of natural eye fluids out of the eye.

HOW should this medicine be used?

Omidenepag isopropyl ophthalmic comes as a solution (liquid) to instill in the eye. It is usually instilled in the affected eye(s) once a day in the evening. If omidenepag isopropyl is used with other topical eye medications, allow at least 5 minutes between each medication. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use omidenepag isopropyl exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Omidenepag isopropyl controls glaucoma and ocular hypertension but does not cure them. Continue to use omidenepag isopropyl eye drops even if you feel well. Do not stop using omidenepag isopropyl eye drops without talking to your doctor.

To instill the eye drops, follow these steps:

  • Wash your hands thoroughly with soap and water.
  • Check the dropper cap to make sure that it is not chipped or cracked.
  • Shake the bottle gently before each use.
  • Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.
  • While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.
  • Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.
  • Brace the remaining fingers of that hand against your face.
  • While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.
  • Blink you eye a few times to help spread the solution over your entire eye.
  • Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Place a finger on the tear duct and apply gentle pressure for 2 minutes.
  • Wipe any excess liquid from your face with a tissue.
  • Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.
  • Wash your hands to remove any medication.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before using omidenepag isopropyl,

  • tell your doctor and pharmacist if you are allergic to omidenepag isopropyl, any other medications, or any of the ingredients in omidenepag isopropyl eye drops. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • tell your doctor if you have had cataract surgery or if you have or ever had macular edema (swelling of the back of the eye) or other inflammation of the eye, including iritis (uveitis; swelling and irritation inside the eye). Also, tell your doctor immediately if you have an eye injury or eye infection.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using omidenepag isopropyl eye drops, call your doctor.
  • if you are having eye surgery, tell the doctor that you are using omidenepag isopropyl eye drops.
  • you should know that omidenepag isopropyl may cause blurred vision or other problems with your eyesight and may make your eyes sensitive to bright light. Do not drive a car or operate machinery until you know how this medication affects you.
  • if you wear contact lenses, remove them before instilling omidenepag isopropyl. You may put them back in 15 minutes after you instill the drops.

What should I do IF I FORGET to take a dose?

Instill the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Omidenepag isopropyl may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dry eyes
  • pain after instilling the medication

    Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • new or worsening eye pain, headache, sensitivity to light, blurred vision, vision changes, redness or swelling of the eye or eyelid, or change in appearance of the eyes

Omidenepag isopropyl may change your eye color to brown or a deeper shade of brown. This color change usually occurs slowly, but it may be permanent. Omidenepag isopropyl also may cause darkening of the eyelid and skin around your eyes and an increase in the length, thickness, color, or number of your eyelashes or fine hair on your eyelids. The eyelash changes and any darkening of the skin around the eyes usually goes away when you stop using omidenepag isopropyl eye drops. If you use omidenepag isopropyl eye drops in only one eye, you should know that there may be a difference in color between your eyes after using the medication. Call your doctor if you notice these changes.

Omidenepag isopropyl may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the bottle it came in, tightly closed, and out of reach of children. Store unopened bottles in the refrigerator. Opened bottles can be stored at room temperature and away from excess heat and moisture (not in the bathroom). Dispose of the bottle 31 days after opening, even if there is some solution left in the bottle.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor. Your doctor will order certain eye tests to check your response to omidenepag isopropyl eye drops.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: November 15, 2022.
AHFS® Patient Medication Information™. © Copyright, 2024
Powered by Krames by WebMD Ignite